Ganglioside (Asialo-GM1, GM1, GM2, GD1a, GD1b, and GQ1b) Antibodies
Order Name
GANLGI PN2
Test Number: 5565951
Revision Date 03/07/2024
Test Number: 5565951
Revision Date 03/07/2024
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
Asialo-GM1 Antibodies, IgG/IgM
|
Semi-Quantitative Enzyme-Linked Immunosorbent Assay | 44737-5 |
|
GM1 Antibodies, IgG/IgM
|
Semi-Quantitative Enzyme-Linked Immunosorbent Assay | 63244-8 |
|
GM2 Antibodies, IgG/IgM
|
Semi-Quantitative Enzyme-Linked Immunosorbent Assay | 63249-7 |
|
GD1a Antibodies, IgG/IgM
|
Semi-Quantitative Enzyme-Linked Immunosorbent Assay | 48656-3 |
|
GD1b Antibodies, IgG/IgM
|
Semi-Quantitative Enzyme-Linked Immunosorbent Assay | 26870-6 |
|
GQ1b Antibodies, IgG/IgM
|
Semi-Quantitative Enzyme-Linked Immunosorbent Assay | 31674-5 |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 1 mL (0.6 mL) | Serum | Clot Activator SST | Refrigerated |
| Instructions | Separate serum from cells ASAP. Specimen Type: Gel-barrier tube Specimen Storage: Refrigerated Special Instructions: Testing referred to ARUP TC 51033 Specimen Stability: Ambient: Not Available, Refrigerated : 2 weeks, Frozen: 1 year |
|||
| GENERAL INFORMATION | |
|---|---|
| Expected TAT | 6 - 10 days |
| Clinical Use | Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barre syndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80% of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease. |
| Performing Labcorp Test Code | 830700 |
| Notes | Labcorp Test Code: 830700 |
| CPT Code(s) | 83516x6 |
| Lab Section | Reference Lab |