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Labcorp Oklahoma, Inc.
Test Directory


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Sjogren's SSA Ro52 Antibody

Order Name SjogrenSSA Ro52
Test Number: 5599890
Revision Date 01/06/2020
Test Name Methodology LOINC Code
Sjogren's SSA Ro52
Chemiluminescence Assay 56549-9 
Sjogren's SSA Ro52 Interpretation
Interpretive information.  
SPECIMEN REQUIREMENTS
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 1 mL (0.5 mL) Serum Clot Activator SST Frozen
Instructions Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection.
Stability: Room Temperature 8hrs, Refrigerated:  48hrs, Frozen:  30 days. 
 
GENERAL INFORMATION
Testing Schedule Mon-Fri 
Expected TAT 1-3 Days  
Clinical Use
SSA/Ro52 and Ro60 antibodies
Anti-SSA/Ro antibodies may be present in patients with a range of autoimmune disorders, including systemic lupus erythematosus (32%), Sjögren's syndrome (59%), idiopathic inflammatory myopathies (19%), systemic sclerosis (21%), mixed connective tissue disease (29%), rheumatoid arthritis (15%), primary biliary cholangitis/primary biliary cirrhosis and undefined connective tissue disease. The prevalence of anti-Ro60 and anti-Ro52 antibodies in patients with SLE was reported to be 49% and 43%, respectively. In patients with Sjögren's syndrome, these antibodies were detected in 67% and 75% of affected individuals. The presence of anti-Ro52 antibodies may be associated with more severe disease. The prevalence of the two types (Ro52 & Ro60) of anti-Ro antibodies diverge in patients with other autoimmune diseases. Anti-Ro52 antibodies but not anti-Ro60 antibodies were detected in patients with idiopathic inflammatory myopathies (35% versus 0%), and anti-Ro52 was more common than anti-Ro60 in patients with systemic sclerosis (19% versus 6%) and Mixed Connective Tissue Disease (29% versus 19%). Women with anti-Ro antibodies, with or without anti-La antibodies and with or without autoimmune disease, are at increased risk for having a child with neonatal lupus syndrome. 
CPT Code(s) 86235
Lab Section Immunology - Serology