Plasminogen Activator Inhibitor-1 (PAI-1) Genotype
Order Name
PLAS ACT G
Test Number: 1517000
Revision Date 12/12/2022
Test Number: 1517000
Revision Date 12/12/2022
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
Plasminogen Activator Inhibitor-1 (PAI-1) Genotype
|
Polymerase Chain Reaction |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 1 mL | EDTA Whole Blood | EDTA (Lavender Top) | Room Temperature |
| Instructions | Specimen Type: Lavender-top (EDTA) tube or yellow-top (ACD) tube Specimen Storage: Maintain specimen at room temperature. Stability: Room temperature up to 8 days Refrigerated up to 8 days Special Instructions: Testing performed at Esoterix Coagulation Lab UY#129100 |
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| GENERAL INFORMATION | |
|---|---|
| Expected TAT | 5-7 Days |
| Clinical Use | The 4G allele within in the promoter region of the PAI-1 (SERPINE1) gene is associated with higher plasma PAI-1 activity when compared with the 5G allele. Heterozygosity or homozygosity for the 4G allele confers a risk for venous thromboembolism (VTE), especially in individuals with other thrombophilic risk factors, as well as a risk for myocardial infarction. Variant Tested: The PAI-1 promoter 4G/5G polymorphism located in the promoter region of the SERPINE1 gene. NM_000602.3(SERPINE1) c.-817dupG (from start of translation). |
| Performing Labcorp Test Code | 500309 |
| Notes | Labcorp Test Code: 500309 |
| CPT Code(s) | 81400 |
| Lab Section | Reference Lab |