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Labcorp Oklahoma, Inc.
Test Directory


Sickle Cell, Fetal Analysis

Order Name Sickle Cell Fetal
Test Number: 5194951
Revision Date 03/21/2023
Test Name Methodology LOINC Code
Sickle Cell, Fetal Analysis
Polymerase Chain Reaction  
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 4 mL (3 mL) Amniotic Fluid Sterile Screwtop Container Room Temperature
Alternate 1 See Instructions See Instructions See Instructions Room Temperature
Instructions Specimen Type: Amniotic fluid or chorionic villus sample (CVS) or cultured cells or cordblood. Direct amniotic fluid or CVS specimen may be submitted; additional culture fee may be applied.
Specimen Volume: Amniotic fluid: 10 mL or CVS: 10 mg or amniotic fluid and CVS culture: one confluent T-25 flask or 4 mL cordblood. If amniotic fluid or CVS are cultured at another facility, please maintain back-up cultures.
Mininum Volume: Amniotic fluid: 10 mL or CVS: 10 mg or amniotic fluid and CVS culture: one confluent T-25 flask or 3 mL cordblood
Collection: Standard sterile techniques. Transfer aseptically to sterile tubes. Amniotic fluid: Discard first 2mL of fluid aspirated to avoid maternal cell contamination.
Specimen Storage: Maintain specimen at room temperature. Do not freeze.

**THIS TEST IS FOR FETAL TESTING ONLY** It is not intended for routine sickle cell screening. Labcorp clients with 8 digit client account numbers should call 800-345-4363 and Labcorp Genetics & Women's Health clients with 6 digit client /subclient account numbers should call 800-255-7357 to speak with a laboratory genetic coordinator before collecting specimens. In some circumstances, specimens from both parents and other family members may be required. All fetal specimens, including cordblood, must be accompanied by a maternal blood, PurFlock buccal swab kit or Oragene Dx 500 saliva kit for maternal cell contamination (MCC). A separate requisition should be submitted with the maternal specimen.
Expected TAT 8 - 14 days If culture is needed, an additional 14-21 days may be required.  
Clinical Use Sickle cell analysis: HbS (c.20A>T, p.Glu7Val) and HbC (c.19G>A, p.Glu7Lys) pathogenic variants are identified by Sanger sequencing, capillary gel electrophoresis and fluorescence detection. Maternal cell contamination analysis (MCC): Analysis of short tandem repeat markers by multiplex fluorescent polymerase chain reaction (PCR) and capillary electrophoresis 
Performing Labcorp Test Code 482091 
Notes Labcorp Test Code: 482091
Lab Section Reference Lab