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Labcorp Oklahoma, Inc.
Test Directory


Herpes Virus Culture and Typing

Order Name C/T Herpes
Test Number: 6000455
Revision Date 03/18/2024
Test Name Methodology LOINC Code
Herpes Virus Culture and Typing
Enzyme-linked virus-inducible system (ELVIS®)  
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred See Instructions Swab Viral Transport Media Refrigerated
Instructions Specimen: Vesicular fluid, ulcerated lesions, pharyngeal and throat swabs, urine, cerebrospinal fluid (CSF), autopsy and biopsy material, eye exudates, vaginal swabs.
Volume: Swab in viral transport media, 1 mL fluid, 0.5 g tissue in transport medium
Container: Viral, Chlamydia, or Mycoplasma culture transport provided by LabCorp, or other appropriate transport medium; body fluids and tissue samples may be submitted in viral transport media or in a sterile leakproof container.
Collection: Specimen is best collected within the first three days after appearance of lesion but no more than seven days. After collection, remove cap from the transport media tube and insert swab aseptically into transport tube and break swab shaft. Replace cap so that swab will not interfere with closure and allow tube to leak. Label tube with patient identification and transport to the laboratory at 4°C.
Stability: Refrigerated 7 Days.
Causes for Rejection: Bacterial swab specimen; specimen received in grossly leaking transport container; dry specimen; specimen submitted in fixative or additive; specimen received in expired transport media or incorrect transport device; inappropriate specimen transport conditions; specimen stored or transported greater than seven days refrigerated; specimen stored or transported at room temperature; wooden shaft swab in transport device; unlabeled specimen or name discrepancy between specimen and test request label.

AOE Prompt Code:  HSV Source  5194924
Expected TAT 2 - 5 days from set up  
Clinical Use Detects Herpes Simplex infections. Infectious HSV is rarely present in CSF during encephalitis, resulting in a poor recovery by culture (<5% in adults, <50% in children). Studies have shown a >98% detection of HSV DNA in CSF by polymerase chain reaction (PCR), and this method is now considered the standard for diagnosis of HSV encephalitis. For HSV PCR testing, please request test 138651. HSV is occasionally isolated from the CSF of patients with HSV-2 meningitis and of neonates with congenital herpes, and from urine of patients with primary genital HSV infections concurrent with cystitis. 
Performing Labcorp Test Code 008250 
Notes Methodology: Enzyme-linked virus-inducible system (ELVIS®). ELVIS® HSV was developed using a transgenic baby hamster kidney-21 cell line. In this cell line, HSV infection causes the expression of a beta-galactosidase “reporter gene”, and it is the expression of this gene that can be used to monitor infection by HSV. Cultures positive by ELVIS® are confirmed by immunofluorescent staining.
CPT Code(s) 87255
Lab Section Reference Lab