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Neisseria Meningitidis IgG Vaccine Response

Order Name NEIS M VAC
Test Number: 5513425
Revision Date 02/22/2022
Test Name Methodology LOINC Code
Neisseria meningitidis Serogroup A IgG
Quantitative Multiplex Bead Assay 28546-0 
Neisseria meningitidis Serogroup C IgG
Quantitative Multiplex Bead Assay 28547-8 
Neisseria meningitidis Serogroup Y IgG
Quantitative Multiplex Bead Assay 60466-0 
Neisseria meningitidis Serogroup W-135 IgG
Quantitative Multiplex Bead Assay 60465-2 
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 1mL (0.25) Serum Clot Activator SST Refrigerated
Instructions Collect: Serum separator tube. Postimmunization specimen should be drawn 30 days after immunization and, if shipped separately, must be received within 60 days of preimmunization specimen.
Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an Serum separator tube. (Min: 0.25 mL). MARK SPECIMENS CLEARLY AS PRE- OR POSTPNEUMOCOCCAL VACCINE SO SPECIMENS WILL BE SAVED AND TESTED SIMULTANEOUSLY.
Storage/Transport Temperature: Refrigerated. Pre- and postpneumococcal vaccine specimens can be submitted separately or together for testing. Unacceptable Conditions: Plasma or other body fluids. Contaminated, hemolyzed or severely lipemic specimens
Stability: After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Testing Schedule MonOnce a week, volume dependant. 
Expected TAT 1-8 days  
Clinical Use This assay measures serum IgG antibodies recognizing polysaccharide antigens from the four Neisseria meningitidis serogroups included in the licensed meningococcal vaccine. The meningococcal vaccine response is best evaluated by testing pre-vaccination and post-vaccination samples in parallel. A two-fold or greater increase for at least two serogroups is expected when comparing post-vaccination to pre-vaccination results. N. meningitidis IgG levels peak approximately one month post-vaccination, but decline markedly by two years. 
Notes Testing includes the following Serogroups:
Serogroup A, Serogroup C, Serogroup Y and Serogroup W-135.

Reference Lab: ARUP
Test Code: 2001603
Click Here to view information on the ARUP website.
CPT Code(s) 86741x4
Lab Section Reference Lab