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KRAS Mutation Analysis (K-ras)

Test Number: 9100040
Revision Date 01/25/2022
Test Name Methodology LOINC Code
KRAS Mutation Analysis (K-ras)
Polymerase Chain Reaction  
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred See Below Tissue Paraffin Block Room Temperature
Instructions Formalin fixed paraffin embedded tissue. Tissue source and block ID containing tumor are required on the requisition form.
Pathology permission is required for any alternate sample types.
Testing Schedule Wednesday 
Expected TAT 7-10 Days  
Clinical Use The presence of a KRAS mutation has been shown to confer resistance to anti-EGFR chemotherapy in both colorectal carcinoma and non-small cell lung adenocarcinomas. (Mutations detected: 12CYS, 12VAL, 12ASP, 12ALA, 12SER, 13ASP) 
Notes Fresh Tissue may be submitted for processing in our histology department or tissue blocks may be used from earlier hospital stays or other encounters, but the KRAS Mutation order should be placed on the patient's current encounter specific to the ordering physician and client account.

Click here for Molecular Pre-Authorization information.
Please submit this test for Pre-Authorization when the patient has United Healthcare insurance.
CPT Code(s) (Pre-Authorization Required)
81275, plus G0452 for Molecular Pathology Interpretation, possible 88381 for Microdisection
Lab Section Molecular Diagnostic