APOE Alzheimer's Disease Risk
Order Name
APOE Alzheimer DR
Test Number: 5197135
Revision Date 04/17/2025
Test Number: 5197135
Revision Date 04/17/2025
| Test Name | Methodology | LOINC Code |
|---|---|---|
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APOE Alzheimer's Disease Risk
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Illumina SNP Array | See Below |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 1 Tube | Whole Blood | EDTA (Lavender Top) | Refrigerated |
| Alternate 1 | 1 Tube | EDTA Whole Blood | ACD Solution A or B (Yellow Top) | Refrigerated |
| Alternate 2 | 1 Tube | Whole Blood | Sodium Heparin (Green Top / No-Gel) | Refrigerated |
| Instructions | Specimen: 1 tube whole blood. (Refrigerated for optimal stability) Container: Lavender-top (EDTA) tube (preferred), yellow-top (ACD) tube or green-top (heparin) tube. Collection: Invert tube immediately eight to 10 times once tube is filled at time of collection. Stability Requirements: Room temperature 3 days for whole blood; Refrigerated 60 days; Frozen n/a Cause for Rejection: Wrong specimen container; mislabeled specimen |
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| GENERAL INFORMATION | |||||||||||||||||||||||||
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| Expected TAT | 5 - 7 days | ||||||||||||||||||||||||
| Clinical Use | Alzheimer's disease is a progressive neurodegenerative disorder that affects more than 6.7 million Americans ages 65 and older and is the most common form of dementia in the elderly. Signs and symptoms may include cognitive decline, memory loss, loss of problem-solving skills and personality changes. Clinical symptoms appear after 60-65 years in 95% of cases. The development of late-onset disease may be influenced by age, sex, family history, level of education, history of head trauma and other factors including cardiovascular risk factors. Approximately 15-20% of late-onset disease may be familial. The APOE gene is a known susceptibility gene for Alzheimer's disease. The APOE gene encodes apolipoprotein E, which has a role in lipid metabolism. APOE has three common alleles: E2, E3 and E4. The presence of the E4 allele increases the lifetime risk of Alzheimer's disease but is neither necessary nor sufficient for the development of Alzheimer's disease. APOE E2 may have some protective effect against development of late-onset disease.1 APOE also has a rate allele: E1 (legacy name E3r). There is insufficient evidence to assess the clinical association of APOE E1 with Alzheimer's disease.2 1. Goldman JS, Hahn SE, Catania JW, et al. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med. 2011 Jun;13(6):597-605.21577118 2. Murrell JR, Price BM, Baiyewu O, et al. The fourth apolipoprotein E haplotype found in the Yoruba of Ibadan. Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):426-427.16583434 |
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| Notes |
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| CPT Code(s) | 81401 | ||||||||||||||||||||||||
| Lab Section | Reference Lab | ||||||||||||||||||||||||