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Labcorp Oklahoma, Inc.
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Treponemal Antibody Analyzer

Order Name Treponemal AB AN
Test Number: 5500607
Revision Date 05/04/2025
Test Name Methodology LOINC Code
Treponemal Antibody Analyzer
Chemiluminescence Assay 47236-5 
SPECIMEN REQUIREMENTS
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 3 mL (0.6 mL) Serum Clot Activator SST Refrigerated
Instructions Stability: Ambient 3 days. Refrigerated 7 days. Frozen 30 days.
GENERAL INFORMATION
Testing Schedule Mon - Sat 
Expected TAT 1-2 Days 
Clinical Use
Treponemal Antibody (CLIA) Non-Treponemal (RPR) Treponemal Antibody (TPPA) Result Long Name
Non-Reactive Not performed Not performed No laboratory evidence of syphilis. If recent exposure is suspected, submit a new sample for testing in 2-4 weeks
Reactive Non-Reactive Non-Reactive Treponemal antibodies not confirmed. Inconclusive for syphilis; potentially early syphilis, possible false positive. If recent exposure is suspected, submit a new sample for testing in 2-4 weeks. If clinical suspicion is low, no further evaluation is necessary.
Reactive Non-Reactive Reactive Treponemal antibodies detected. Consistent with past or current (potentially early) syphilis. Clinical evaluation should be performed to identify current signs and symptoms or past history of infection. If past history of treatment reported, no further management is needed unless symptomatic or recent exposure suspected. If no symptoms or past history of treatment, and if recent exposure is suspected, submit a new sample for testing in 2-4 weeks.
Reactive Reactive Not performed Treponemal and nontreponemal antibodies detected. Consistent with past or current syphilis. Clinical evaluation should be performed to identify current signs and symptoms or past history of infection.
 
Notes The Treponemal Antibody Analyzer screen reactive specimens will reflex to an Non-Treponemal Antibody (RPR) and titer (Test Code 5500605), at additional charge(s). The Non-Treponemal Antibody (RPR) assay is performed to distinguish recent/active from past infection. A Non-Reactive Non-Treponemal Antibody (RPR) assay will reflex a second treponemal assay Treponemal Antibodies, TPPA (Test Code 5501065), at additional charge(s). The presence of maternal Treponemal Antibody (Syphilis specific Antibody) in a baby can be detected up to 15-18 months. Therefore, only a Non-Treponemal antibody (RPR) [5500605] assay will be performed on babies <18 months.

Click Here to view testing algorithm.
CPT Code(s) 86780 (possible 86780 and 86592)
Internal Comments 7/14/2014 - built and put online... hidden until official go live 10/13/14 - jk
4/28/17 - added keywords for non-trep antibody and test code. JLS
10/23/17 changed from immuno to chem - JK
11/8/17 added link to rpr test code
6/15/18 Stability: Room Temperature: 8 hrs, Refrigerated 7 days, Frozen: 30 days  to
Stability: Ambient 3 days. Refrigerated 7 days. Frozen 30 days.  JK
12/18/18: Updated Notes SN
3/22/19 removed this text below for new version on Notes - JK
All screening chemiluminescent immunoassay reactive patients will have an Non-Treponemal Antibody (RPR) performed to distinguish recent/active from past infection. The screen reactive specimen will reflex to an Non-Treponemal Antibody (RPR) and titer (RML Test Code 5500605), if necessary, at additional charge(s). RPR-negative specimens will reflex a second treponemal assay (TP-PA, RML Test Code 5501065), if necessary, at additional charge(s).
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4/5/25 change from 24110-9 to 47236-5
 
Lab Section Immunology - Serology