Multiple Myeloma Profile by FISH
Order Name
MULT MYEL
Test Number: 9115585
Revision Date 10/01/2024
Test Number: 9115585
Revision Date 10/01/2024
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
Multiple Myeloma Profile by FISH
|
Fluorescence in Situ Hybridization |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 5 mL (1 mL) | Bone Marrow | Sodium Heparin (Green Top, No-Gel) | Room Temperature |
| Alternate 1 | 5 mL (3 mL) | Whole Blood | Sodium Heparin (Green Top, No-Gel) | Room Temperature |
| Instructions | Send specimen ASAP, Keep at room temperature! (DO NOT FREEZE). Frozen samples will be rejected. | |||
| GENERAL INFORMATION | |
|---|---|
| Testing Schedule | Mon-Fri |
| Expected TAT | 3-5 Days |
| Clinical Use | Multiple Myeloma (MM) is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. In most cases, there is low proliferation index of terminally different malignant plasma cells. As a result, conventional cytogenetic analysis frequently yields normal results. The most frequent abnormalities with prognostic association have been included in this panel: [TP53 deletion, 1p deletion, 1q gain, t(4;14); IGH::FGFR3 fusion, t(14;16);IGH::MAF fusion, t(14;20);IGH::MAFB, t(11;14)IGH::CCND1, and t(14;20);IGH::MAFB]. Interphase FISH studies can enhance the detection rate and complement conventional cytogenetic techniques. |
| Notes | Tricore test code: FMM |
| CPT Code(s) | 88377x6 |
| Internal Comments | changed 88368x2, 88368-TCx6 to 88368, 88369x7 5/11/18 changed from 88368, 88369x7 to 88377x4 - JK 4/16/24 changed from 88377x4 to 88377 x5 per Tricore website for # FMM, Telcor is already correct with x5 hdm 9/30/24 updated from 88377x5 to 88377x6 10/1/24 updated markers in clinical use section per S. Lamb email. hdm |
| Lab Section | Reference Lab |