Cold Agglutinin Antibody
Order Name
COLD AGG
Test Number: 5500450
Revision Date 07/10/2025
Test Number: 5500450
Revision Date 07/10/2025
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
Cold Agglutinin Antibody
|
Hemagglutination | 5098-9 |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 1 mL (0.5mL) | Serum | Clot Activator (SST or Red No-Gel) | Refrigerated |
| Instructions | Specimen: 1mL (0.5mL) Serum from Red-top tube or gel-barrier tube Collection: Transport blood immediately to laboratory. Incubate at 37°C and allow to clot at 37°C. Separate serum from cells. If there is not a 37°C incubator, allow to clot at room temperature and separate serum from cells immediately after clotting. Storage Requirements: Refrigerated Storage Instructions: Do not refrigerate prior to separation of serum from red cells. Store separated serum in refrigerator. Cause for Rejection: Refrigeration of the specimen before separating serum from cells |
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| GENERAL INFORMATION | |
|---|---|
| Expected TAT | 3-4 Days |
| Clinical Use | Cold agglutinin disease must be considered for all patients with acquired hemolytic anemia who have a positive direct antiglobulin test. Also suspected for patients with chronic liver disease, certain viral infections and Mycoplasma pneumoniae infection. |
| CPT Code(s) | 86157 |
| Internal Comments | JK 5/12/17 updated collection instructions becuase OKC thinks it is not clear enough and want Do Not Refrigerate on instructions. Was: "Allow blood to clot for 30 mins at 37 degrees C. Serum must be kept at 37 degrees C until separated from cells. Transport warm if not centrifuged. Fasting specimen preferred." Now: "Fasting specimen preferred. Allow blood to clot for 30 mins at 37'C - Serum must be kept at 37'C until separated from cells. Transport specimen Warm if not centrifuged. Do Not Refrigerate or Freeze!" 7/10/25 removed Protein electrophoresis performed if cold agglutinin is positive. (84155; 84165; 80500). 32672-8 to 5098-9- JK |
| Lab Section | Reference Lab |