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Lupus Anticoagulant Analyzer

Order Name LUP ANT AN
Test Number: 1506300
Revision Date 10/19/2021
Test Name Methodology LOINC Code
Activated Partial Thromboplastin Time (aPTT)
Clot Detection 3184-9 
Beta-2-Glycoprotein IgG and IgM Antibody
Chemiluminescence Assay See Panel Details 
Cardiolipin Antibodies, IgM and IgG
Chemiluminescence Assay See Panel Details 
Dilute Russell Viper Venom (DRVVT) Profile
Assay Dependant See Panel Details 
Lupus Anticoagulant PTT
 
Prothrombin Time (PT) and INR
 
Pathology Report
 
SPECIMEN REQUIREMENTS
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred See Instructions See Instructions Sodium Citrate 3.2% (Blue Top) and Clot Activator SST See Instructions
Instructions Due to the national shortage of 3.2% sodium citrate blue top tubes - Note change in tubes to collect.
Please list the patient's anticoagulant on the "Coagulopathy Questionnaire Form" and submit with specimen or fax to 918-744-3236.
Please collect both Serum and Plasma as indicated below:
Seven: 2.7mL Sodium Citrate Blue top tubes    Each 2.7mL Sodium Citrate 3.2% (Blue Top) tube must be filled to the proper level, no hemolysis. Improperly filled tubes can give erroneous results. Whole blood must be transported to lab immediately.
If testing cannot be started within 4 hours of collection the specimen must be double spun then 1.5mL plasma aliquot from each tube into individual plastic aliquot tubes and freeze.  Do not pool aliquots together!
One: 5mL Clot Activator SST  Centrifuge and Refrigerate the serum tube.
(Serum specimen must be drawn within 72 hours of other specimens if not collected at the same time.)
GENERAL INFORMATION
Testing Schedule Individual Test Dependant 
Expected TAT 5 Days  
Clinical Use This analyzer is designed to evaluate patients in whom there is a clinical suspicion of a lupus anticoagulant or clinical features of the anti-phospholipid syndrome (e.g. thrombocytopenia, thrombosis, recurrent abortion).
Not recommended when patients are taking Pradaxa®, Xarelto® and Apixaban® See More Information. 
CPT Code(s) The algorithm begins with a Prothrombin Time (PT/INR), Partial Thromboplastin time (PTT), Lupus Sensitive PTT, Dilute Russell Viper Venom Panel, Beta 2 Glycoprotein IgG/IgM Antibodies and Cardiolipin IgG/IgM testing. Subsequent tests are generated based on the results of this first level of testing. A pathology interpretation is included with all orders. For more information on this Analyzer, access our "Specialized Tests" section of this guide for a complete listing of tests and CPT codes.
Lab Section Coagulation